How Can I Get a Headache from Just One Glass of Wine?

The Most Likely “Culprits”

1. Sulfites
Sulfites are preservatives used in wine. While most people don’t have issues with them, some can experience reactions like headaches or mild dizziness.
⚠️ However, sulfites are actually found in higher amounts in dried fruits and rarely cause headaches on their own.

2. Histamines
Red wines, because they ferment with the grape skins, contain more histamines than whites. These substances can trigger headaches in sensitive individuals. If this happens often, try white wine or wines low in histamines.

3. Tannins
Tannins give wine body and structure but can sometimes affect blood flow to the brain, causing or worsening headaches. Reds and full-bodied wines have more tannins — trying lighter reds or rosés might help.

4. Dehydration
Even one glass of alcohol can cause dehydration, especially if you haven’t eaten well or drunk enough water during the day. Dehydration is one of the most common headache triggers.

How to Prevent It

• Drink water alongside your wine — a glass of water for every glass of wine is good practice.

• Avoid overconsumption and sip slowly.

• Try different varieties or colors of wine. A light white might suit you better than a bold red.

• Check labels for low-sulfite or sulfite-free wines.

What If It Keeps Happening?

If headaches happen consistently even with small amounts, it’s a good idea to consult a doctor or nutritionist. Some people are more sensitive to certain compounds, and it might not be the wine itself — it could be related to overall diet or hydration.

Bottom Line

Wine itself isn’t always to blame.
A headache after wine is annoying but usually has an explanation and a fix. With a little attention, the right wine choice, and good hydration, you can keep enjoying your glass without worries.

Cheers — and here’s to headache-free wine nights!